Characterization of Apelin/APJ axis expression in Normal Testicular Tissue, Germ Cell Neoplasia In Situ, and Testicular Seminoma

Aim: A testicular germ cell tumour is not observed widely, but its incidence and mortality rates have increased in recent years. One of the most common forms this seminoma. Germ neoplasia situ (GCNIS) precursor The apelin/APJ axis many cancers a pathway that plays an active role angiogenesis, lymphangiogenesis, growth, migration. This study investigated cellular distributions apelin APJ protein expressions normal tissue (TT), GCNIS, seminoma.Material Methods: Tissues from 18 patients who had undergone orchiectomy were used study. These tissues include areas TT, Immunolocalisation identified through immunohistochemical method.Results: Apelin expression was significantly seminoma GCNIS compared to normal. same GCNIS. Normal similar.Conclusion: Expressions proteins our Our findings consistent with results relevant studies as has been different cancers. It can be predicted increase may support migration, metastasis. Therefore, related axis. Ultimately, use inhibitors these reduce their rate. New are needed before clinically.